BDB - Target Details

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Target

Target Name: Enantiomeric Lipid I(ent-Lipid I)

Target ID:

1631

Target Type:

Organic molecules or materials

Target Sequence:

Synonyms:

Target Source:

Unknown

Target Structure:

Comments:

Phage display screens made use of lipid I inspired targets in both natural and enantiomeric forms. First, by doing so the amount of chemical space explored in the screen is effectively doubled. Secondly, it was considered that L-peptides selected in the screen that possess high affinity for natural lipidI/II might in fact be toxic towards the E.coli used in the amplification step of the phage display experiment, so using enantiomeric forms was viewed as a way of avoiding any such negative selection bias.

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