The October 13, 2023 release offers the following new features: (Click here to download this version of the data )

The core data of the BDB database are sets of biopanning data and related information such as sequences, structures, targets, templates and libraries. Peptides are grouped into a set of biopanning data if they are from the same independent experiment. In the current release, 34,078 peptides grouped into 3,682 sets are collected from 1,770 published papers.Among the 34,078 peptides in BDB, 28,858 peptides appear only in one set of biopanning data; however, there are 2,007 peptides appearing in two or more sets of biopanning data for 5,220 times in total. 


BiopanningDataSet:


Table 1: Biopanning data set distribution based on experimental method

      Experimental method        Number of set of biopanning data
Phage display (common panning)2315
Phage display (subtractive panning)720
Phage display (competitive panning)300
Phage display (in vivo)197
Phage display (subtractive panning, in vivo)11

Phage display (subtractive panning,competitive panning)

64
mRNA display (common panning)13
mRNA display (subtractive panning)5
mRNA display (competitive panning)6
Ribosome display (common panning)4
Ribosome display (subtractive panning)2
Ribosome display (competitive panning)3
Bacterial display (common panning)17
Bacterial display (subtractive panning)4
Bacterial display (competitive panning)5
Yeast display (common panning)          7          

 

Target:

 

There are 2231 different targets in the current version of BDB. Besides 201 targets with undetermined sources and 190 targets with no sources (such as cellulose, polystyrene, microplate, etc.), most of the targets are from Homo sapiens (Human) and Mus musculus (Mouse). The source of some targets are a hybrid of two or more species.

 

Table 2-1: Target distribution based on target type

Target type        Number of target  
Organ and tissue126
Cell227
Virus24
Protein>Monoclonal antibody529
Protein>Polyclonal antibody238
Protein>Receptor97
Protein>Enzyme137
Protein>Others483
Nucleic acids30
Organic molecules or materials67
Inorganic molecules or materials145
Miscellaneous         108         

 

Table 2-2: Target distribution based on target source

       Target source               Number of target   
Homo sapiens(Human)778
Mus musculus(Mouse)547
Others511
Unknown201
None   190   

 

Template:

 

For most of the peptides in the BDB database, their templates are not or even can not be determined. Thus, there are only 593 templates identified.

 

Table 3-1: Template distribution based on template type

      Template type        Number of template 
Cell12
Virus23
Protein>Monoclonal antibody10
Protein>Polyclonal antibody5
Protein>Receptor39
Protein>Enzyme44
Protein>Others378
Nucleic acids2
Organic molecules or materials60
Inorganic molecules or materials6
Miscellaneous4
Organ and tissue2

 

Table 3-2: Template distribution based on template source

   Template source     Number of template  
Homo sapiens(Human)214
Mus musculus(Mouse)22
Others284
Unknown55
None       18        

 

Structure:

 

Table 4: Complex structure and related sets of biopanning data

  Complex    Target-template Target-peptideIn Total 
Structure number27739316
Related sets of biopanning data17110189*
Related targets70878*
Related templates646  70*  

 

Library:

 

In the current version of the BDB database, there are 528 phage libraries or library pools.

 

Table 5-1: Library distribution based on randomness

         Library randomness            Number of library  
Completely random340
Semi-random       174      

 

Table 5-2: Library distribution based on topology

 Library topology  Number of library 
Linear303
Circular184
Mixture(linear, circular)

                            49