BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 963

Peptides:

Sequences
KNGPWYAYTGRD FGILTEEMYRRW LRYTQEEMYRRW HYVHEDLYRRVK VTGYTMDVLYRR

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 8170958

Target Name:

Purified IgM lamda receptor of the human Burkitt lymphoma cell line SUP-B8

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

12-mer GG-pIII phage display library

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

All the peptides bound to the SUP-B8 immunoglobulin specifically. Their binding could be inhibited with anti-Id antibodies but not with anti-IgM or anti-lamda light-chain antisera. When conjugated to form dimers or tetramers, they induced cell death by apoptosis in vitro with an IC5o between 40 and 200 nM. This effect was associated with specific stimulation of intracellular protein tyrosine phosphorylation.

Curator:

Curation Date:

0000-00-00

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