BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 843

Peptides:

Sequences
CAGPRPNPS(13) CAGPRPALG(6) CAGPRPPHC(1) CKTNDNTQC(1) CQGDPSHHC(1) CLNTSSMTC(1) CSTAVGPQC(1) CELSARGMC(1) CNHQHNNAC(1) CKSGLTPTC(1) CRVNFQNVC(1)

Sequences Features:

Motif:

GPRP

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 10677284

Target Name:

High molecular mass serum fraction

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-C7C phage display library (CX7C)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

Here this procedure is used to probe a mixture of high molecular mass components of human cord blood with phage-peptide display libraries. The initial panning recovered phage that bore the consensus motif Gly-Pro-Arg-Pro, a known fibrinogen-binding motif. These phage bound specifically to purified fibrinogen. A series of peptides containing the Gly-Pro-Arg-Pro motif efficiently blocked the binding of phage having the same motif, presumably by binding to their common target.

Curator:

Curation Date:

0000-00-00

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