BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 842

Peptides:

Sequences

HLHGTPRPSSGL(12)
HLHGTPRMLPPL(3)
GPRPPLPPALPL(2)
GPRPPVAGSWPF(2)
GPRPWPPQELSR(1)
GPRPPAALPHPL(1)
GPRPPSLPPDPA(1)
GPRPSMGLATNL(1)
GPRPLNPPDKLP(1)
GPRPVYPRHDYT(1)
GPRPPSATAFPP(1)
GPRPAHPPPLTH(1)
GPRPPASNFSFG(1)
GPRPHTILTSPS(1)
GPRPATTWYPNS(1)
GPRPSLSHAHNW(1)
GPRPAWTSPTFI(1)
GPRPPSTHWMQQ(1)
GPRPNFPSLPTQ(1)
GPRPNPLTVALH(1)
GPRPPITMPMFM(1)
GPRPVHNTFYYA(1)
GPRPATYMPPSL(1)
GPRPLYTLSPHT(1)
LLAGPRPPSMHV(1)

Sequences Features:

Motif:

GPRP

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 10677284

Target Name:

High molecular mass serum fraction

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-12 phage display library (X12)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

Here this procedure is used to probe a mixture of high molecular mass components of human cord blood with phage-peptide display libraries. The initial panning recovered phage that bore the consensus motif Gly-Pro-Arg-Pro, a known fibrinogen-binding motif. These phage bound specifically to purified fibrinogen. A series of peptides containing the Gly-Pro-Arg-Pro motif efficiently blocked the binding of phage having the same motif, presumably by binding to their common target.

Curator:

Curation Date:

0000-00-00

First |

Prev |

842

| Next

| Last