BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 729

Peptides:

Sequences
CIVPWGRYC(6) CLIPWGRFC(4) CLVPWGRYC(3) CAVPWARYC(3) CAVPWGRLC(3) CLVPWARWC(2) CKVPWARWC(1) CLVPWGRLC(1) CNVPWGRYC(1) CDVPWRDLC(1) CVPWRDWTC(1) CIPWGRYFC(1) CAVPWGRYC(1) CIVPWARYC(1)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 15946218

Target Name:

Integrin alpha-IIb-beta-3, integrin αIIbβ3

Template Name:

von Willebrand factor (vWF)

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

CX7C phage display library

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

A CX7C phage display library was used to search for peptides that bind to integrin αIIbβ3 in the presence of GRGDS. Sequencing of the bound phage revealed only four RGD-containing sequences (CWARGDFRC, CEPRGDWRC, CVARGDWRC, CWARGDPRC). Consistent with \r\nselection strategy the majority of sequences lacked RGD and revealed novel binders. The consensus in these sequences was the tri-amino acid motif Val-Pro-Trp (VPW).

Curator:

Curation Date:

0000-00-00

First |

Prev |

729

| Next

| Last