BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 492

Peptides:

Sequences
ETPLTETALKWH(29) FNGSHIYSPFHP(7) HLQDGSPPSSPH(6) APVPPTAWWHLS(5) QWNLTPRQSLQL(4)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 19226949

Target Name:

Anti-H5N1 virus monoclonal antibody 8H5

Template Name:

Hemagglutinin

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-12 phage display library (X12)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

Sixty positive clones were sequenced. ETPLTETALKWH was further displayed on the virus-like particle assembled from aa 1-149 fragment of HBcAg. The chimeric particle conserved the specific binding to 8H5 mAb, and competed with H5N1 viruses for 8H5 mAb.

Curator:

Curation Date:

0000-00-00

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