BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 3331

Peptides:

Sequences
CDWPDWQCYGWSSHC CKHQAQECVAIREGC CWAMPMWCDSWSQNC CRPQKFNCISANIRC CKAMIGACVAMQFAC CYPVDWYCLFQTVDC

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Next generation sequencing

Rounds of Panning:

Reference:

PMID: 29568446

Target Name:

Bacterial cell wall precursor lipid I

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

CX6CX6C phage display library

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

We identiﬁed unique lipid II binding peptides that upon lipidation were found to be active against a range of Grampositive bacteria including clinically relevant strains of vancomycin resistant bacteria. Optimization of the peptide sequence led to variants with enhanced antibacterial activity and reduced hemolytic activity.

Curator:

Ying Wang

Curation Date:

2018-07-23

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