BDB - Target Details

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Target

Target Name: Bacterial cell wall precursor lipid I

Target ID:

1259

Target Type:

Organic molecules or materials

Target Sequence:

Synonyms:

Target Source:

Unknown

Target Structure:

Comments:

Phage display screens made use of lipid I inspired targets in both natural and enantiomeric forms.First,by doing so the amount of chemical space explored in the screen is effectively doubled.Secondly,it was considered that L-peptides selected in the screen that possess high affinity for natural lipidI/II might in fact be toxic towards the E.coli used in the amplification step of the phage display experiment ,so using enantiomeric forms was viewed as a way of avoiding any such negative selection bias.

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