BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 3128

Peptides:

Sequences

YAAHRSH(5/50)
KFPAINQ(5/50)
GVQSPHF(4/50)
VPFPSAS(2/50)
GIHTLMG(2/50)
ATWVSPY(2/50)
GSTPNWH(2/50)
IDPQTPT(2/50)
ADRAWAR(2/50)
NHRPHLD(1/50)
TNPHLNW(1/50)
AFPSPTD(1/50)
STSPESA(1/50)
ALHGPTP(1/50)
APSFTKH(1/50)
DFHHASM(1/50)
FPPFQTQ(1/50)
GHYSAGC(1/50)
HSAHENS(1/50)
ISPQTPT(1/50)
LIAASNN(1/50)
LPPSSRM(1/50)
NSHSMPF(1/50)
QFATQSH(1/50)
QIGYQRA(1/50)
QSFWFHA(1/50)
SVSPISH(1/50)
TPLTPHQ(1/50)
TSSHAPL(1/50)
VALSAPY(1/50)
VAPWEKL(1/50)
VIIVPPA(1/50)
YIPTAMK(1/50)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger Sequencing

Rounds of Panning:

Reference:

PMID: 28252649

Target Name:

Metacaspase, MCA

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-7 phage display library (X7)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

Four peptides, NHRPHLD, YAAHRSH, ATWVSPY and AFPSPTD, were selected for their capacity to specifically bind to MCA and interfere with its activity. The peptide with the sequence of YAAHRSH, similar to ecotin-like ISP3 of L. (L.) major, decreases trypsin-like activity of promastigotes under heat shock, and significantly decreases parasite heat shock-induced death.

Curator:

Bifang He

Curation Date:

2017-04-11

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