BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 2835

Peptides:

Sequences

Affinity Values

ACDARPCPQTYCL(28)
SCGGRPCPPAYCK(22)
GCLGRPCPMAYCS(13)
DCPVVWCLQKACR(7)
VCVQKFCWRGWCP(4)
QCNARPCPSSYCR(2)
GCMGRPCPVSYCF(2)
ACQQQFCWRGWCP(2)
LCEYTLCWRGWCP(2)
HCRYVFCWRGWCP(2)
WCVMQKCLMQYCE(2)
YCVKDKCLQAMCS(2)
SCGGPRCWPSTCR(1)
RCGQGFCSPVKCR(1)
ICKSQVCVSFSCG(1)
GCWARPCPLALCQ(1)
GCAARPCPLTACW(1)
GCHGRPCPLQYCK(1)
RCYANPCPISYCR(1)
SCSGRRCPPSYCK(1)
NCVNRYCWRGWCS(1)
SCVVGKCLVQYCA(1)
HCVQGKCLVYMCG(1)
QCVPFKCLLHLCA(1)
GCVLGKCLQDFCQ(1)
YCVPLKCLWDRCE(1)
RCSAGGCCERVCE(1)
TCTTQGCAFRLCS(1)
WCTHQRCVKARCC(1)
YCQGTKCVKERCC(1)
LCQPRKCVKALCC(1)
SCANQRCVKSLCC(1)
TCLCKRCIKELCC(1)
VCTYRKCVKELCC(1)
GCQARACAKFLCC(1)
GCGRNICVKNLCC(1)

[20.5 ± 5.2]
[3.1 ± 0.5]
[5.0 ± 1.5]
[46.9 ± 3.2]
[>75]
[4.7 ± 1.5]
[5.0 ± 1.3]
[NT]
[NT]
[NT]
[NT]
[NT]
[NT]
[NT]
[NT]
[10.2 ± 4.6]
[33.5 ± 5.9]
[11.2 ± 4.4]
[NT]
[7.8 ± 3.2]
[NT]
[NT]
[NT]
[NT]
[NT]
[NT]
[NT]
[>75]
[NT]
[NT]
[NT]
[NT]
[NT]
[NT]
[NT]
[NT]

Sequences Features:

Motif:

[AG]-R-P-C-P, WRGW, V-K-x-[RL]

Unique Sequence Number:

Experimental Method:

Phage display (subtractive panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 23586812

Target Name:

Human beta-FXIIa

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

XCX4CX4CX phage display library

Affinity Measurement Method:

Inhibition assay

Affinity Measurement Description:

Several bicyclic peptides presenting common sequence elements were chemically synthesized and their inhibitory activity (Ki, μM) is indicated. All indicated inhibitory constants Kis are averages of at least three measurements. NT denotes not tested.

Brief Description:

In the second round, neutravidin-coated magnetic beads were used to prevent the enrichment of streptavidin-specific peptides.

BiopanningDataSet Comments:

Curator:

Curation Date:

0000-00-00

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