BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 1904

Peptides:

Sequences

PSTRKK(1)
TGGWRF(2)
QWPMLV(1)
WSGQDI(1)
YRRGHL(1)
RYRTSL(2)
SWGRRG(1)
VRKVAA(2)
SRSCTA(1)
LEALVV(1)
SACLTG(1)
CLKTEG(1)
FRRPGG(1)
RGWGTV(1)
LRYVTY(1)
GGRVVT(1)
RVYLLS(1)
RAQMGE(1)
PVQKKH(1)
VGRHLA(1)
KGWEGC(1)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 22132161

Target Name:

Serine protease 28

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

X6 T7 phage display library

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

Phage display peptide mimetics revealed an expanded but mixed substrate specificity of ISP1, including chymotryptic and elastase activity. Based upon targets observed using phage display, we hypothesised that ISP1 might signal to cells by cleaving and activating proteinase-activated receptors (PARs) and therefore assessed PARs 1, 2 and 4 as potential ISP1 targets.

Curator:

Curation Date:

0000-00-00

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