BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 1659

Peptides:

Sequences
YQVARMLRRVADQMAS(7) KVVMRQLLMIADTMAR(1) LTVARRLKWVADIIFA(1)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

mRNA display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 20181936

Target Name:

B-cell lymphoma/leukemia 10

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

X(2)-V-X-R-X-L-X(4)-D-X-I-X(2) mRNA display library

Affinity Measurement Method:

Fluorescence polarization

Affinity Measurement Description:

To evaluate the affinity of the selected peptides for the BH3-recognition site of Bcl-XL, competition fluorescence polarization assay was performed. The selected peptide B01 (YQVARMLRRVADQMAS) (IC50= 6.4 μM) showed marked inhibitory activity.

Brief Description:

BiopanningDataSet Comments:

Curator:

Curation Date:

0000-00-00

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