BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 1056

Peptides:

Sequences
CNGRCVSGCAGRC(0.26) CGRECPRLCQSSC(0.15) CGEACGGQCALPC(0.06)

Sequences Features:

Motif:

NGR

Unique Sequence Number:

Experimental Method:

Phage display (in vivo)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 9430587

Target Name:

Mice carrying human MDA-MB-435 breast carcinoma xenografts

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

CX3CX3CX3C phage display library

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

Endothelial cells in the angiogenic vessels within solid tumors express several proteins that are absent or barely detectable in established blood vessels. CX3CX3CX3C library was screened in mice carrying human MDA-MB-435 breast carcinoma xenografts. Phage displaying CNGRCVSGCAGRC, homed selectively to breast cancer xenografts. This homing can be inhibited by the free CNGRCVSGCAGRC, but not by the CNGRC peptide, even when this peptide was used in amounts 10 times.

Curator:

Curation Date:

0000-00-00

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