BDB - Template Details

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Target
Template
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Structure

Template

Template Name: Abciximab

Template ID:

352

Template Type:

Protein>Monoclonal antibody

Template Sequence:

Synonyms:

Template Source:

Homo sapiens (Human):9606, Mus musculus (Mouse):10090

Template Structure:

Comments:

Abciximab, ReoPro (abciximab) T, is the Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation. Abciximab also binds to the vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells. The chimeric 7E3 antibody is produced by continuous perfusion in mammalian cell culture. The 47,615 dalton Fab fragment is purified from cell culture supernatant by a series of steps involving specific viral inactivation and removal procedures, digestion with papain and column chromatography.

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