BDB - Target Details

Target

Target Name: Envelope glycoprotein gp120 (SU)

Target ID:

530

Target Type:

Protein>Others

Target Sequence:

P04578 [33-511]

Synonyms:

Glycoprotein 120, gp120

Target Source:

Human immunodeficiency virus type 1 (isolate HXB2 group M subtype B) (HIV-1):11706

Target Structure:

1AIK, 1DF4, 1DF5, 1DLB, 1G9M, 1GC1, 1GZL, 1K33, 1K34, 1RZJ, 2CMR, 2NY7, 2PV6, 2XRA, 3DNL, 3DNN, 3DNO, 3IDX, 3IDY, 3TYG, 3VIE, 4JPJ, 4JPK

Comments:

The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. Surface protein gp120 (SU) may target the virus to gut-associated lymphoid tissue (GALT) by binding host ITGA4/ITGB7 (alpha-4/beta-7 integrins), a complex that mediates T-cell migration to the GALT. The surface protein gp120 is also a ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses. These interactions allow capture of viral particles at mucosal surfaces by these cells and subsequent transmission to permissive cells.

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