BDB - Target Details

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Target

Target Name: Hepatitis A virus cellular receptor 1, HAVcr-1

Target ID:

2060

Target Type:

Protein>Receptor

Target Sequence:

Q96D42

Synonyms:

Kidney injury molecule 1
KIM-1
T-cell immunoglobulin and mucin domain-containing protein 1
TIMD-1
T-cell immunoglobulin mucin receptor 1
TIM
TIM-1
T-cell membrane protein 1
CD_antigen: CD365

Target Source:

Homo sapiens (Human):9606

Target Structure:

5DZO, 5F70

Comments:

Kidney injury molecule-1 (KIM-1), also known as hepatitis A virus cellular receptor-1 and T cell Ig mucin-1, is a transmembrane protein, which is not overexpressed in normal kidneys, but is significantly upregulated in damaged kidney tubular epithelial cells in toxic and ischemic acute kidney injury. KIM-1 is comprised of an extracellular segment containing a mucin domain and six cysteine Ig-like domains and a cytosolic segment containing a tyrosine kinase phosphorylation motif.

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