BDB - Target Details

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Target Name: Anti-Claudin 18.2 monoclonal antibody IMAB362

Target ID:

1482

Target Type:

Protein>Monoclonal antibody

Target Sequence:

Synonyms:

Target Source:

Mus musculus (Mouse):10090

Target Structure:

Comments:

IMAB362 (anti-Claudin 18.2) is a highly tumor-specific monoclonal IgG1 antibody currently in clinical development for the treatment of advanced gastro-esophageal and stomach cancer. The antibody is directed against the cancer-specific cell surface target Claudin 18 isoform 2 (CLDN18.2), a 27.7 kDa gastric differentiation protein that spans the cell membrane with four transmembrane helices. IMAB362 is derived from a murine monoclonal antibody, and has been chimerized to display the human IgG1 constant region. For clinical development, IMAB362 is produced in Chinese Hamster Ovary (CHO) cells by standard recombinant expression technology.

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