BDB - Target Details

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Target

Target Name: Proprotein convertase subtilisin/kexin type 9, PCSK9

Target ID:

1447

Target Type:

Protein>Enzyme

Target Sequence:

Q8NBP7

Synonyms:

EC=3.4.21.-
Neural apoptosis-regulated convertase 1
NARC-1
Proprotein convertase 9
PC9
Subtilisin/kexin-like protease PC9

Target Source:

Homo sapiens (Human):9606

Target Structure:

2P4E, 2PMW, 2QTW, 2W2M, 2W2N, 2W2O, 2W2P, 2W2Q, 2XTJ, 3BPS, 3GCW, 3GCX, 3H42, 3M0C, 3P5B, 3P5C, 3SQO, 4K8R, 4NMX

Comments:

PCSK9 is an ideal antibody target because it circulates in blood and has only modest binding affinity to cell surface LDL receptor and its main interaction site is an exposed 500-Å2 slightly convex region that is readily available for antibody binding.

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