BDB - Target Details

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Target

Target Name: Fibroblast growth factor 8, FGF-8

Target ID:

1330

Target Type:

Protein>Others

Target Sequence:

P55075

Synonyms:

Androgen-induced growth factor
AIGF
Heparin-binding growth factor 8
HBGF-8

Target Source:

Homo sapiens (Human):9606

Target Structure:

2FDB

Comments:

FGF8 belongs to the fibroblast growth factor family of at least 23 members. Alternative splicing of the human FGF8 gene allows transcription of four different isoforms designated FGF8a, FGF8b, FGF8e, and FGF8f. FGF8b is the real target. It has also been found to have a strongly angiogenic and transforming potential in comparison to FGF8a and FGF8e. FGF8b is expressed and secreted by the epithelium, and it signals directionally to mesenchyme by binding FGFR3c, FGFR4, FGFR2c, or FGFR1c.

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