BDB - Target Details

Target

Target Name: Glutamate carboxypeptidase 2 EC=3.4.17.21

Target ID:

1285

Target Type:

Protein>Enzyme

Target Sequence:

Q04609

Synonyms:

Cell growth-inhibiting gene 27 protein
Folate hydrolase 1
Folylpoly-gamma-glutamate carboxypeptidase
FGCP
Glutamate carboxypeptidase II
GCPII
Membrane glutamate carboxypeptidase
mGCP
N-acetylated-alpha-linked acidic dipeptidase I
NAALADase I
Prostate-specific membrane antigen
PSM
PSMA
Pteroylpoly-gamma-glutamate carboxypeptidase

Target Source:

Homo sapiens (Human):9606

Target Structure:

1Z8L??

Comments:

There are high frequencies of prostate-specific membrane antigen (PSMA) overexpression in all stages and grades of PCa patients. PSMA is a 100-kDa transmembrane glycoprotein with folate hydrolase activity (hydrolysis of the terminal glutamates fromclinked polyglutamates) as well as NAALADase activity (hydrolysis of the terminal glutamate from the neuropeptide NAAG), which was found not only in normal prostate epithelium but also in the central nervous system and the proximal gastrointestinal tract.

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