BDB - Target Details

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Target

Target Name: Phosphorylated ERα LBD, ERα LBD-P

Target ID:

1267

Target Type:

Protein>Others

Target Sequence:

Synonyms:

Target Source:

Unknown

Target Structure:

Comments:

The Estrogen Receptor (ER) belongs to the Nuclear Receptor (NR) superfamily of ligand-inducible transcription factors that bind to DNA response elements and cofactor proteins to control gene transcription. There are two ER isoforms, ERα and ERβ, which both bind estradiol as a natural ligand and share the multidomain features of NRs, which includes a C-terminal Ligand Binding Domain (LBD) with significant homology (60%). ERa LBD-P contained a phosphorylated Y537.

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