BDB - Target Details

BiopanningDataSet
Target
Template
Library
Structure

Target

Target Name: p53-binding domains of MDMX

Target ID:

1110

Target Type:

Protein>Others

Target Sequence:

O15151 [24-108]

Synonyms:

MDMX alternative name(s):
Protein Mdm4
Double minute 4 protein
Mdm2-like p53-binding protein
Protein Mdmx
p53-binding protein Mdm4

Target Source:

Homo sapiens (Human):9606

Target Structure:

2CR8, 2VJE, 2VJF, 2VYR, 3DAB, 3EQY, 3FDO, 3FE7, 3FEA, 3JZO, 3JZP, 3JZQ, 3LBJ, 3MQR, 3U15

Comments:

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

First |

Prev |

1110

| Next

| Last