BDB - Target Details

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Target

Target Name: Regulatory protein E2

Target ID:

1085

Target Type:

Protein>Others

Target Sequence:

P03120

Synonyms:

Target Source:

Human papillomavirus type 16:333760

Target Structure:

1BY9, 1DTO, 1R8P, 1ZZF, 2NNU, 2Q79, 3MI7

Comments:

Plays an accessory role in initiation of DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.

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