BDB - Target Details

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Target

Target Name: Guanine nucleotide-binding protein G(i) subunit alpha-1

Target ID:

1044

Target Type:

Protein>Others

Target Sequence:

P10824

Synonyms:

Adenylate cyclase-inhibiting G alpha protein

Target Source:

Rattus norvegicus (Rat):10116

Target Structure:

1AGR, 1AS0, 1AS2, 1AS3, 1BH2, 1BOF, 1CIP, 1GDD, 1GFI, 1GG2, 1GIA, 1GIL, 1GIT, 1GP2, 1SHZ, 1SVK, 1SVS, 2BCJ, 2ZJY, 2ZJZ, 3AH8, 3D7M, 3FFA, 3FFB, 3V00

Comments:

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane.

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