BDB - Structure Details

Structure

Complex ID: 316

Complex Structure:

3M17

Struture Interface:

A-I,C-J,E-K,G-L,G-K

Site On Target:

[A-i]>A:A81+GG(83,84)+Y88+LN(112,113)+E115+WPE(131-133)
[C-J]>C:ALGG(81-84)+Y88+LN(112,113)+E115+WPE(131-133)
[E-K]>E:ALGG(81-84)+Y88+LN(112,113)+E115+WPE(131-133)
[G-L]>G:ALGG(81-84)+Y88+LN(112,113)+E115+WPE(131-133)+A136
[G-K]>G:QP(261,262)

Site On Binder:

[A-I]>I:TGHFG(Sar)(4-9)+Y(11)
[C-J]>J:TGHFG(Sar)(Mle)Y(4-11)+(LE)13
[E-K]>K:TGHFG(Sar)(Mle)Y(4-11)
[G-L]>L:TGHF(4-7)+(Sar)9+Y11+(LE)13
[G-K]>K:C13+(NH)214

Comments:

The consensus motif was discovered Using peptide phage display screening, Gly-His-Phe-Gly-Gly-X-Tyr, where X is preferably a hydrophobic amino acid. The motif is enclosed by a cysteine disulfide loop forming an 11-amino acid loop including the cysteines. The peptide was optimized for inhibition of IgG binding to FcRn and stability in plasma, resulting in monomeric peptide1 SYN1327 and dimeric peptide3 SYN1436. The structures of peptides 1 and 3 in complex with degshFcRn and diffraction data have been deposited with the RCSB Protein Data Bank (entry IDs: 3M17 and 3M1B,respectively).

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