BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 848

Peptides:

Sequences
CRYRGDLGRRC(8)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 11006114

Target Name:

Madin-Darby canine kidney cells strain II, MDCKII

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

pVIII-9aa.Cys phage display library (CX9C)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

MDCK strain II (MDCKII) cells transfected with a rabbit receptor for polymeric immunoglobulins (pIgR) were kindly provided by Dr. K. E. Mostov (University of California).

BiopanningDataSet Comments:

The identified peptide contained a putative integrinbinding (RGD) motif suggesting the involvement of integrins, but not pIgR, in phage transcytosis. The paper data suggest the feasibility of using short peptides for targeting transcytotic pathways nand facilitating delivery of macromolecules across cellular barriers.

Curator:

Curation Date:

0000-00-00

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