BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 80

Peptides:

Sequences	Affinity Values
ANTPCGPYTHDCPVKR(0.800) AYTKCSRQWRTCMTTH(0.013) LTGTCLQYQSRCGNTR(0.013) NISRCTHPFMACGKQS(0.013) PRNICSRRDPTCWTTY(0.013)	[72.2 ± 32.8] [5.7 ± 2.2] [NA] [NA] [NA]

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 15528216

Target Name:

Galectin-3, Gal-3

Template Name:

Thomsen--Friedenreich glycoantigen, TFAg

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

f88-Cys6 phage display library (X4CX6CX4)

Affinity Measurement Method:

Fluorescence titration

Affinity Measurement Description:

Dissociation constant (Kd, nM) described the binding of peptides to galectin-3.

Brief Description:

BiopanningDataSet Comments:

The results demonstrate that carbohydrate-mediated, metastasis-associated tumor cell adhesion could be inhibited efficiently with short synthetic peptides which do not mimic naturally occurring glycoepitopes yet bind to the galectin-3 carbohydrate recognition domain with high affinity and specificity.

Curator:

Curation Date:

0000-00-00

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