BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 719

Peptides:

Sequences
CQSHKLPSC(2) CVGNDNSSC(1) CKPETAPLC(1) CKLPVPPHC(1) CEHPPYLQC(1) CTSSDHLQC(1) CIAPTHNLC(1) CKTHHNLIC(1) CPDALPSSC(1) CSTLAFPLC(1) CQSALTGVC(1) CTTLQSAQC(1) CPFSLSALC(1)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (in vivo)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 17384922

Target Name:

Tumor endothelial cells, TEC

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-C7C phage display library (CX7C)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

Mice (n=4 per round) were injected intravenously with 1e11 PFU of the whole phage library. After 15 min of circulation time, the animals were killed, and the number of phages localizing to TEC formed vessels as well as to murine kidney (control murine tissue) was determined.

BiopanningDataSet Comments:

No such enrichment was seen in the mouse kidneys, suggesting the isolation of specific phages that preferentially bound to human tumor vessels rather than to mouse normal vasculature.

Curator:

Curation Date:

0000-00-00

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