BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 47

Peptides:

Sequences
MDDRGLLLVKKKKHG(24) KKKRHDVEKHIPHVRAS(18) FDGVRKKSRGKSLEY(15) RRGDHDHDIFHWWVH(11) FLDERNYIKKKRHKL(5) SIEVLRGAMHVAPRR(1) GGWYDRKHRRPAPLS(1) KFFRKKSHYHSRTTS(1)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 7649995

Target Name:

Heat shock cognate 71 kDa protein

Template Name:

BAG family molecular chaperone regulator 1

Structure of Target-Template Complex:

1HX1

Structure of Target-Peptide Complex:

Not determined.

Library Name:

X15 phage display library

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

The peptides containing basic sequences with at least KK, KR or RR were enriched. A similar synthetic heptamer NIVRKKK had the highest affinity for Hsc70, and substitution analyses showed that hydrophobic residues followed by basic residues play important roles in maintaining this affnity.

Curator:

Curation Date:

0000-00-00

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