BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 450

Peptides:

Sequences
CAYHRLRRC

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

2-4

Reference:

PMID: 18292083

Target Name:

Acute T-lymphoblastic leukemia Molt-4 cells

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

fUSE5-based CX7C phage display library

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

Ninety-six clones were sequenced after the second, third, and fourth round of panning. There were 1, 17 and 55 clones respectively had the sequence CAYHRLRRC. CAYHRLRRC contains a lymph node-homing motif (CAY) and a cell-penetrating motif (RLRR). Binding of this ligand-directed phage to a large panel of leukemia/lymphoma cells and to patient-derived samples was much higher than to non-leukemia control cells.

Curator:

Curation Date:

0000-00-00

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