BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 378

Peptides:

Sequences

SVSVGMKPSPRP(25)
WPLHTSVYPPSP(11)
NTLPPFSPPSPP(5)
SFPDSNIAPSSP(3)
QHAPSNSKSVLT(2)
WPTYLNPSSLKA(1)
GPSGNLHIRPAS(1)
SPLLSTRAVQLS(1)
SPMFTMIQGDAQ(1)
VNSHQALWSPAQ(1)
STLPPPLRFANV(1)
SFNQPYLYKTAF(1)
YHTRIALPDNLP(1)
AQSTAFQKPLLM(1)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (in vivo)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 18006841

Target Name:

Non-small cell lung cancer (CL1-5)

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-12 phage display library (X12)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

CL1-5 cells (lung cancer cell line) were injected s.c. into SCID mice to produce lung cancer xenografts.

BiopanningDataSet Comments:

The paper suggested that PSP motif was crucial for peptide binding to the tumor neovasculature. The most frequent peptide SVSVGMKPSPRP was shown to be a good candidate for targeted drug delivery to solid tumors.

Curator:

Curation Date:

0000-00-00

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