BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 3618

Peptides:

Sequences
GAQTCMN(15)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 36353454

Target Name:

Mycolic acid

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-7 phage display library (X7)

Affinity Measurement Method:

ELISA

Affinity Measurement Description:

Absorbance was measured at 450 nm and reproduced from Figure 1D and shown.

Brief Description:

BiopanningDataSet Comments:

The efficacy of APTX4870 (GAQTCMN) against mycolic acid was demonstrated by evaluating clinical samples and conducting in vitro and Vivo. APTX4870 inhibited apoptosis, increased autophagy to decrease inflammation, and reduced Mycobacterium-derived mycolic acid (M.tb-MA)-induced lung damage. These findings suggest that this heptapeptide, which selectively targets M.tb-MA, might be exploited as a potential novel M.tb therapeutic treatment.

Curator:

Bowen Li

Curation Date:

2023-10-13

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