BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 3466

Peptides:

Sequences

Affinity Values

NCKFSGCSVSVCH
NCRFSGCLQTMCV
NCRFSGCGTVACV
NCRFSGCGFKVCV
NCKFSGCPWELCI
NCRFSGCVWAKCS
NCKFSGCQESMCS
NCRFSGCQWGDCA
NCKFSGCQFLGCE
SCKFSGCHRKPCT
SCRFTFCYYQPCA
NCRFTFCNLNLCG
NCRFTFCEFGRCE
NCRFSLCESMACL
NCKFSACYLTTCY
QCWDRGCENRKCN
SCLFTFCYFVPCN
TCRQSMCTARTCP
DCRWSSCTARTCA
TCGVQACLSARCY
GCSDQACWSARCV
NCKFSGCAQLRCY
NCRYSGCFDRPCI
NCRFTLCGLAPCG
NCRYSGCFDRPCI
NCYFSNCGAHSAE
RCLLSACTARACN
GCAQSVCTARYCE
GCSPSRCTARFCP
GCQTSQCTARTCL
RCLPSWCSARTCF
SCPPSRCTARTCP
GCRESSCSARTCP
ACRVSSCTARTCS
ECRASDCSARVCW
WCQASDCTARACI
VCRQSDCSRRTCI
VCRSSDCTKRSCE
PCGEQACYTARCR
LCLSQACWSARCA
GCSAQACASARCL
GCSVQACFSGRCT
GCSQDACYSARCV
ICSVLGCLSARCG
GCGTLACQTARCR
VCVERGCSTARCR
LCADVSCATARCR
GCVRPSCFSARCS
ECQDRSCPFTMCS

[5.13]
[8.77]
[10.85]
[5.75]
[0.78]
[16.90]
[1.74]
[23.41]
[2.96]
[1.53]
[111.10]
[29.41]
[>200]
[71.18]
[>200]
[1.72]
[>200]
[11.56]
[8.65]
[12.9]
[10.50]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]
[NA]

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

2/3

Reference:

PMID: 24453110

Target Name:

Urokinase-type plasminogen activator

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

XCX4CX4CX phage display library

Affinity Measurement Method:

Inhibition assay

Affinity Measurement Description:

The inhibition constants Ki (μM) were determined by incubating different concentrations of bicyclic peptide with fixed concentration of human urokinase-type plasminogen activator. The indicated Ki values are averages of at least two measurements.

Brief Description:

The peptide library was cyclized with the thiol-reactive compound 1,3,5-tris(bromomethyl)benzene (TBMB). The library was then subjected to two or three iterative rounds of phage selection against human urokinase-type plasminogen activator.

BiopanningDataSet Comments:

Curator:

Bifang He

Curation Date:

2019-08-17

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