BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 2844

Peptides:

Sequences

Affinity Values

CAWPARCLTVDLC
CRWPARCVHQDLC
CRWPARCLTTSLC
CAWPAKCLTRELC
CAWPARCLTTSLC
CSWPARCNHQDLC
CRWPARCTHQNYC
CTWPARCTHQNWC
CTWPARCTMQNYC
CSWPYRCLHQDYC
CNWPYRCLHTDLC
CGVPYRCTHQEMC
CTYPYKCLHQNLC
CADPWACLFRRPC
CGGPQNCRTWTTC
CGGYNNCRAFSYC
CFPSHDCDGRRMC

[0.4 ± 0.1]
[0.3]
[NT]
[NT]
[0.9 ± 0.1]
[NT]
[2.9 ± 1.2]
[NT]
[NT]
[NT]
[NT]
[NT]
[12.2 ± 4.8]
[NT]
[4.3 ± 0.2]
[NT]
[5.3 ± 2.8]

Sequences Features:

Motif:

PAR

Unique Sequence Number:

Experimental Method:

Phage display (subtractive panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 22492508

Target Name:

Plasma kallikrein (EC:3.4.21.34)

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

CX5CX5C phage display library

Affinity Measurement Method:

Inhibition assay

Affinity Measurement Description:

Target specificity of bicyclic peptides was indicated by the Ki values (nM) of these peptides against hPK.

Brief Description:

In the second round of selection, neutravidin-coated magnetic beads were used to prevent the enrichment of streptavidin-specific peptides.

BiopanningDataSet Comments:

Curator:

Curation Date:

0000-00-00

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