BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 2618

Peptides:

Sequences
SIGYPLP(45) MSPPGPA(33) LSNFHSS(2)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (subtractive panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 10889136

Target Name:

Human umbilical vein endothelial cells, HUVECs

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-7 phage display library (X7)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

Phages were biopanned on HUVECs after biopanning on 2 successive cultures of VSMCs, HepG2 cells, and peripheral blood mononuclear cells (preclearing steps).

BiopanningDataSet Comments:

The peptide SIGYPLP retargeted gene delivery specifically to endothelial cells with a significantly enhanced efficiency over nontargeted adenovirus and without transduction of nontarget cells.

Curator:

Curation Date:

0000-00-00

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