BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 2300

Peptides:

Sequences
LGCDDTAVAHWPWVY SDAYDTAVAHWPGFI MPPNLIANYESALSR YESPGFLLSGYDDTG WAAHPSGPSIVPRSL

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 23939045

Target Name:

Anti-SMN monoclonal antibody MANSMA1-21

Template Name:

Survival motor neuron protein

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

f88-15mer phage display library (X15)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

Three of these 22 mAbs were responsible for the selection process. These mAbs included two of the mostly widely-used for SMA studies, MANSMA1 and MANSMA12, and one mAb against the proline-rich region encoded by exon 5, MANSMA3. Biopanning with the remaining 19 anti-SMN mAbs alone failed to select any further phage clones.

Curator:

Curation Date:

0000-00-00

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