BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 1969

Peptides:

Sequences

HLPLFRHVWPNM(1)
HLSTWLSHSWLR(1)
HLRQTLWNLSTS(1)
HWWQWPSSLQLR(1)
HNWTRWLLHPDR(1)
HWFSAWYQLGSN(1)
HWKPWWFSPGSW(1)
HWWHFYQPPLST(1)
HFSWFLPWNAPL(1)
HFTWWYPGYNTP(1)
HSWFWQAWPPQL(1)
HIRLPTWWGAYP(1)
FHENWPSGGGSA(1)
FHKNWPIWWYPP(1)
WHNPYQLWSWRW(1)
ASQVGPAHTSTV(1)
SDRIPSLRAHTV(1)
ITKSGLTHLYPV(1)
GPQVLANIPHFP(1)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 22606046

Target Name:

72 kDa type IV collagenase

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-12 phage display library (X12)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

The authors showed that M204C4 (HWWQWPSSLQLRGGGS) and M205C4 (HNWTRWLLHPDRGGGS) inhibited the activity of MMP-2 in a dose dependent manner in vitro. Two peptides reduced MMP-2 mediated invasion of the pancreatic cancer cell lines PANC-1 and CFPAC-1, but not affected the expression and release of MMP-2. Furthermore, these two peptides could suppress tumor growth in vivo.

Curator:

Curation Date:

0000-00-00

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