BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 1943

Peptides:

Sequences
EPLQLKM(10) IPTLPSS(4) HWGMWSY(3) LTIPTTA(2) MYASSSK(1)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (subtractive panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 22322196

Target Name:

Human bone marrow-derived mesenchymal stem cell, hBMMSCs

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-7 phage display library (X7)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

In the negative selection procedure, the library was incubated with the synovial cells for 1 h to exclude the synovial cell affinity phage clones.

BiopanningDataSet Comments:

The authors identified an MSC-homing peptide EPLQLKM (E7) through phage display and constructed an MSC-homing device by conjugating E7 with PCL electrospun meshes. The E7-conjugated PCL electrospun meshes have shown an apparent MSC-homing property in vivo. In addition, the E7-conjugated PCL electrospun meshes have shown specificity toward MSCs compared with the RGD-conjugated PCL electrospun meshes. The current study offers a promising way to improve MSC-based TE repair.

Curator:

Curation Date:

0000-00-00

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