BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 1645

Peptides:

Sequences
TDSILRSYDWTY(1) TQQPLEGHQLPY(1) TGVSWSVAQPSF(1) SVSVGMKPSPRP(1) SQWNSPPSSAAF(1)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 19137069

Target Name:

Non-small cell lung cancer (CL1-5)

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-12 phage display library (X12)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

The targeting phage TDSILRSYDWTY bound to several NSCLC cell lines but not to normal cells. Both the targeting phage and the synthetic peptide recognized the surgical specimens of NSCLC with a positive rate of 75% (27 of 36 specimens). In severe combined immunodeficiency (SCID) mice bearing NSCLC xenografts, the targeting phage specifically bound to tumor masses. The tumor homing ability of the targeting phage was inhibited by the cognate synthetic peptide, but not by a control or a WTY-mutated peptide.

Curator:

Curation Date:

0000-00-00

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