BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 1462

Peptides:

Sequences

Affinity Values

CWPLSHSVIVC(3)
CYPLNPEVYHC(2)
CSSVTAWTTGC(1)
CYMASGVFLC(1)
CWPLGPSTYIC(1)
CSLIASMETGC(1)
CYIGDPPENPC(1)
CWPLGDSTVIC(1)
CPLRLAFTFGC(1)
CTRMSHGYWIC(1)

[1.504/1.407/1.609]
[1.210/0.809]
[2.304]
[1.464]
[0.865]
[2.360]
[0.665]
[1.713]
[1.910]
[2.015]

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 15131117

Target Name:

Anti-PSA monoclpnal antibody 30H12

Template Name:

Poly-α 2-8 sialic acid, PSA

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

pVIII-9aa.Cys phage display library (CX9C)

Affinity Measurement Method:

ELISA

Affinity Measurement Description:

Reactivity of BSA-coupled peptides with 30H12 anti-PSA Ab was measured by ELISA tests. Absorbances at 492 nm were reproduced from the bar graph and shown. BSA-coupled MK6 and MK11 reverse peptides have values of A < 0.1 (data not shown).

Brief Description:

BiopanningDataSet Comments:

Authors tested mimotopes bioactivity in several in vitro and in vivo tests and demonstrated their ability to enhance PSA biological activity.

Curator:

Curation Date:

0000-00-00

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