BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 1327

Peptides:

Sequences

ELKQSAQVQAKI
HLWSFALPSAQV
INSARIMPPNWR
TSPQARLEAIEP
YSLRQDYNPEPV
YSLRQDVLVLEE
YSLRNDWPTLPP
SLTNSMFPGYAY
HMSIWPERWPLS
HSLRPEWRMPGP
FQIAPTDPASNA
SPKIISSGLPTY
TSSGLAPTPIMQ
FGTGLASHSPAW
HNLVPRHLGTVL
SYQWHHLGTWLT
STYGSHLGWGHF
GIHLNFKVTHMH
WHSTMSWTNSTW
AGHDRLAVTPSS
LTRSLDSHSMNT

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 21071249

Target Name:

Methylmalonic aciduria and homocystinuria type C protein

Template Name:

Methylmalonic aciduria and homocystinuria type D protein, mitochondrial

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-12 phage display library (X12)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

The MMACHC-affinity-selected peptides were scanned against MMADHC to predict binding sites of MMACHC on this protein. Five distinct regions of multiply-aligning clusters were located along the primary sequence of MMADHC. Two regions were positioned in a domain with homology to ATPase component of a bacterial ATP-binding cassette (ABC) transporter: Region I, residues142-150; and Region II, residues 157-169. The other three regions were located in the C-terminal domain of MMADHC: Region III, residues 220-236; Region IV, residues 246-256; and Region V, residues 280-290.

Curator:

Curation Date:

0000-00-00

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