BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 1317

Peptides:

Sequences
RAPMGGR RRPVGRA RLPPKAG RRPVVGR RAPARRY SRPGLRR VGPRTLR RGPRGRV

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 21071869

Target Name:

Soluble 37/48kDa oligomer formation of Aβ(1-42)

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

T7 phage display library (X2PX4)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

BiopanningDataSet Comments:

Although the reason for the enrichment of the arginine residues is not fully understood, highly cationic sequences containing at least three arginine residues are probably important in binding to the soluble Aβ(1-42) structure, because arginine contains a basic guanidine group. These peptides were found to suppress specifically 37/48kDa oligomer formation and to keep the monomeric form of Aβ(1-42) even after 24h of incubation, as disclosed by SDS-PAGE and size-exclusion chromatography.

Curator:

Curation Date:

0000-00-00

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