BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 1228

Peptides:

Sequences
IQSPHFF(8) LPLTPLP(7) NQDVPLF(2) WPKLASH(2) SPAHAAK(1) ASMSVAI(1) AWLPWAK(1) MPNRTAN(1) NLPAYTS(1) CSSVETH(1) GTPTLXS(1) VMPWVHK(1) YAPRLRS(1) APPTRNQ(1)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (competitive panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 11748221

Target Name:

HMG box 2 domain of high mobility group protein B1

Template Name:

Not determined.

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-7 phage display library (X7)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

Peptides were eluted by affinity with the same HMG-box used for the biopanning.

BiopanningDataSet Comments:

A computer search of the protein data bases found peptide homologies with proteins already known to interact with HMGB1, like p53, and have allowed us to identify new potential candidates. Among them, transcriptional activators like the heterogeneous nuclear ribonucleoprotein K (hnRNP K), repressors like methyl-CpG binding protein 2 (MeCP2), and co-repressors like the retinoblastoma susceptibility protein (pRb) and Groucho-related gene proteins 1 (Grg1) and 5 (Grg5) can be found.

Curator:

Curation Date:

0000-00-00

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