BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 1003

Peptides:

Sequences

FGRIPSPLAYTYSFR(15)
HRWMPHVFAVRQGAS(12)
VSWFSRHRYSPFAVS(11)
QLQSYRFFFPSYMGG(5)
WSNRMPPLFTPWYPP(3)
YWALHHSGWPFSRGS(2)
GYPWRIRPWASGPFL(2)
RRLVFWHGFETTGPR(2)
DRWRPALPVVLFPLH(2)
GPWYCTLGLCHFRSS(2)
GWPSFSNHPFLYPRW(2)
LNPFRSLFFPALDNL(2)
LSWPLHAGRGFRVWS(2)
VGFLGLKRGPPGVDA(2)
GRWAFAPSSWHLYSR(2)
GAGMLRWFGYPALYG(2)
SRVRFPAWGLPFSPV(1)
WFPGPITFIPRPWSS(1)
WWMSRPSRLLYYEYG(1)
HRVQFAGWGFPGFRL(1)
WHWRLPRSTWHPTSV(1)

Sequences Features:

Motif:

Unique Sequence Number:

Experimental Method:

Phage display (common panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 8889832

Target Name:

Integrin alpha-6-beta-1, integrin α6β1

Template Name:

Laminin-1

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

f3-15mer phage display library (X15)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

The integrin alpha-6 beta-1 was isolated from human placenta and used as the target.

BiopanningDataSet Comments:

The synthetic peptide VSWFSRHRYSPFAVS was found to strongly inhibit the binding of laminin-1 to integrin alpha-6 beta-1. This inhibitory effect seemed to be specific for alpha-6 beta-1 integrin, since it did not affect the binding of fibronectin to integrin alpha-5 beta-1.

Curator:

Curation Date:

0000-00-00

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