The October 24, 2017 release offers the following new features: (Click here to download this version of the data )

The core data of the BDB database are sets of biopanning data and related information such as sequences, structures, targets, templates and libraries. Peptides are grouped into a set of biopanning data if they are from the same independent experiment. In the current release, 29,333 peptides grouped into 3,264 sets are collected from 1,521 published papers. Among the 29,333 peptides in BDB, 25,043 peptides appear only in one set of biopanning data; however, there are 1,669 peptides appearing in two or more sets of biopanning data for 4,290 times in total.


BiopanningDataSet:


Table 1: Biopanning data set distribution based on experimental method

      Experimental method        Number of set of biopanning data
Phage display (common panning)2071
Phage display (subtractive panning)637
Phage display (competitive panning)248
Phage display (in vivo)169
Phage display (subtractive panning, in vivo)10

Phage display (subtractive panning,competitive panning)

61
mRNA display (common panning)13
mRNA display (subtractive panning)5
mRNA display (competitive panning)6
Ribosome display (common panning)4
Ribosome display (subtractive panning)2
Ribosome display (competitive panning)3
Bacterial display (common panning)16
Bacterial display (subtractive panning)4
Bacterial display (competitive panning)5
Yeast display (common panning)          7          

 

Target:

 

There are 1953 different targets in the current version of BDB. Besides 184 target with undetermined sources and 162 targets with no sources (such as cellulose, polystyrene, microplate, etc.), most of the targets are from Homo sapiens (Human) and Mus musculus (Mouse). The source of some targets are a hybrid of two or more species.

 

Table 2-1: Target distribution based on target type

Target type        Number of target  
Organ and tissue103
Cell206
Virus22
Protein>Monoclonal antibody504
Protein>Polyclonal antibody203
Protein>Receptor82
Protein>Enzyme116
Protein>Others411
Nucleic acids30
Organic molecules or materials57
Inorganic molecules or materials128
Miscellaneous          87          

 

Table 2-2: Target distribution based on target source

       Target source               Number of target   
Homo sapiens(Human)674
Mus musculus(Mouse)502
Others391
Unknown184
None       162       

 

Template:

 

For most of the peptides in the BDB database, their templates are not or even can not be determined. Thus, there are only 542 templates identified.

 

Table 3-1: Template distribution based on template type

      Template type        Number of template 
Cell10
Virus21
Protein>Monoclonal antibody7
Protein>Polyclonal antibody4
Protein>Receptor36
Protein>Enzyme40
Protein>Others351
Nucleic acids2
Organic molecules or materials56
Inorganic molecules or materials6
Miscellaneous4
Organ and tissue1

 

Table 3-2: Template distribution based on template source

   Template source     Number of template  
Homo sapiens(Human)198
Mus musculus(Mouse)19
Others260
Unknown49
None       16        

 

Structure:

 

Table 4: Complex structure and related sets of biopanning data

  Complex    Target-template Target-peptideIn Total 
Structure number27639315
Related sets of biopanning data17810188*
Related targets69877*
Related templates636  69*  

 

Library:

 

In the current version of the BDB database, there are 470 phage libraries or library pools.

 

Table 5-1: Library distribution based on randomness

         Library randomness            Number of library  
Completely random318
Semi-random       160       

 

Table 5-2: Library distribution based on topology

 Library topology  Number of library 
Linear271
Circular166
Mixture(linear, circular)

                41