The January 7, 2011 release offers the following new features: (Click here to download this version of the data )
The core data of the MimoDB database are mimotope sets and related information such as sequences, structures, targets, templates and libraries. Peptides are grouped into a mimotope set if they are from the same independent experiment. In the current release, 11,312 peptides grouped into 1,295 sets are collected from 610 published papers. Among the 11312 peptides in MimoDB, 10,252 peptides appear only in one mimotope set; however, there are 437 peptides appearing in two or more mimotope sets for 1,060 times in total.
Mimoset:
Table 1: Mimotope set distribution based on experimental method
Experimental method | Number of mimotope set |
Phage display (common panning) | 1001 |
Phage display (subtractive panning) | 144 |
Phage display (competitive panning) | 85 |
Phage display (in vivo) | 64 |
Target:
There are 832 different targets in the current version of MimoDB. Besides 79 target with undetermined sources and 37 targets with no sources (such as cellulose, polystyrene, microplate, etc.), most of the targets are from Homo sapiens (Human) and Mus musculus (Mouse). The source of some targets are a hybrid of two ore more species.
Table 2-1: Target distribution based on target type
Target type | Number of target |
Organ and tissue | 41 |
Cell | 77 |
Protein>Monoclonal antibody | 285 |
Protein>Polyclonal antibody | 67 |
Protein>Receptor | 30 |
Protein>Others | 251 |
Nucleic acid | 6 |
Inorganic materials | 27 |
Misc | 48 |
Table 2-2: Target distribution based on target source
Target source | Number of target |
Homo sapiens (Human) | 280 |
Mus musculus (Mouse) | 243 |
Others | 193 |
Unknown | 79 |
None | 37 |
Template:
For most of the peptides in the MimoDB database, their templates are not or even can not be determined. Thus, there are only 273 templates identified.
Table 3-1: Template distribution based on template type
Template type | Number of template |
Cell | 8 |
Protein>Monoclonal antibody | 4 |
Protein>Others | 223 |
Nucleic acid | 1 |
Miscellaneous | 37 |
Table 3-2: Template distribution based on template source
Template source | Number of template |
Homo sapiens (Human) | 120 |
Mus musculus (Mouse) | 6 |
Others | 130 |
Unknown | 14 |
None | 3 |
Structure:
Table 4: Complex structure and related mimotope sets
Complex | Target-template | Target-peptide | In total |
Structure number | 56 | 5 | 61 |
Related mimotope sets | 64 | 4 | 68* |
Related targets | 30 | 4 | 34* |
Related templates | 29 | 3 | 32* |
Library:
In the current version of the MimoDB database, there are 255 phage libraries or library pools.
Table 5-1: Library distribution based on randomness
Library randomness | Number of library |
Completely random | 194 |
Semi-random | 55 |
Mixture(completely random, semi-random) | 6 |
Table 5-2: Library distribution based on topology
Library topology | Number of library |
Linear | 156 |
Circular | 79 |
Mixture(linear, circular) | 20 |