The January 7, 2011 release offers the following new features: (Click here to download this version of the data )

The core data of the MimoDB database are mimotope sets and related information such as sequences, structures, targets, templates and libraries. Peptides are grouped into a mimotope set if they are from the same independent experiment. In the current release, 11,312 peptides grouped into 1,295 sets are collected from 610 published papers. Among the 11312 peptides in MimoDB, 10,252 peptides appear only in one mimotope set; however, there are 437 peptides appearing in two or more mimotope sets for 1,060 times in total.


Mimoset:


Table 1: Mimotope set distribution based on experimental method

                  Experimental method                   Number of mimotope set    
     Phage display (common panning)1001
         Phage display (subtractive panning)144
         Phage display (competitive panning)85
      Phage display (in vivo) 64 


Target:


There are 832 different targets in the current version of MimoDB. Besides 79 target with undetermined sources and 37 targets with no sources (such as cellulose, polystyrene, microplate, etc.), most of the targets are from Homo sapiens (Human) and Mus musculus (Mouse). The source of some targets are a hybrid of two ore more species.


Table 2-1: Target distribution based on target type

             Target type                         Number of target            
Organ and tissue 41
 Cell 77
     Protein>Monoclonal antibody   285
   Protein>Polyclonal antibody  67
 Protein>Receptor   30
 Protein>Others   251
 Nucleic acid   6
 Inorganic materials     27
 Misc       48    


Table 2-2: Target distribution based on target source

            Target source                         Number of target            
Homo sapiens (Human)      280
Mus musculus (Mouse)       243
Others       193
   Unknown       79
None             37      


Template:


For most of the peptides in the MimoDB database, their templates are not or even can not be determined. Thus, there are only 273 templates identified.


Table 3-1: Template distribution based on template type

                     Template type                       Number of template            
                Cell  8
                Protein>Monoclonal antibody   4
                Protein>Others    223
                Nucleic acid  1
                Miscellaneous       37    


Table 3-2: Template distribution based on template source

        Template source                          Number of template            
Homo sapiens (Human)      120
Mus musculus (Mouse)      6
Others       130
Unknown       14
 None              3        



Structure:


Table 4: Complex structure and related mimotope sets

 Complex  Target-template Target-peptide In total  
    Structure number                 56                 5                61            
Related mimotope sets      64                 4                68*            
Related targets     30                 4                34*            
Related templates     29                 3                32*             



Library:


In the current version of the MimoDB database, there are 255 phage libraries or library pools.


Table 5-1: Library distribution based on randomness

           Library randomness                           Number of library            
 Completely random   194
 Semi-random   55
  Mixture(completely random, semi-random)         6        


Table 5-2: Library distribution based on topology

                         Library topology                                 Number of library      
     Linear    156
    Circular     79
             Mixture(linear, circular)      20