The July 23, 2014 release offers the following new features: (Click here to download this version of the data )

The core data of the MimoDB database are mimotope sets and related information such as sequences, structures, targets, templates and libraries. Peptides are grouped into a mimotope set if they are from the same independent experiment. In the current release, 22,418 peptides grouped into 2,463 sets are collected from 1,167 published papers. Among the 22,418 peptides in MimoDB, 19,838 peptides appear only in one mimotope set; however, there are 1,001 peptides appearing in two or more mimotope sets for 2,580 times in total.


Mimoset:

 

Table 1: Mimotope set distribution based on experimental method

Experimental methodNumber of mimotope set
Phage display (common panning)1634
Phage display (subtractive panning)406
Phage display (competitive panning)171
Phage display (in vivo)128
Phage display (subtractive panning, in vivo)9
Phage display (subtractive panning, competitive panning)49
mRNA display (common panning)13
mRNA display (subtractive panning)5
mRNA display (competitive panning)6
Ribosome display (common panning)4
Ribosome display (subtractive panning)2
Ribosome display (competitive panning)3
Bacterial display (common panning)16
Bacterial display (subtractive panning)4
Bacterial display (competitive panning)5
Yeast display (common panning)7


Target:

 

There are 1484 different targets in the current version of MimoDB. Besides 114 target with undetermined sources and 142 targets with no sources (such as cellulose, polystyrene, microplate, etc.), most of the targets are from Homo sapiens (Human) and Mus musculus (Mouse). The source of some targets are a hybrid of two ore more species.

 

Table 2-1: Target distribution based on target type

Target typeNumber of target
Organ and tissue93
Cell149
Virus16
Protein>Monoclonal antibody432
Protein>Polyclonal antibody130
Protein>Receptor62
Protein>Enzyme82
Protein>Others310
Nucleic acids16
Organic molecules or materials48
Inorganic molecules or materials100
Miscellaneous46

 

Table 2-2: Target distribution based on target source

Target sourceNumber of target
Homo sapiens (Human)483
Mus musculus (Mouse)421
Others324
Unknown114
None142

 

Template:

 

For most of the peptides in the MimoDB database, their templates are not or even can not be determined. Thus, there are only 466 templates identified.

 

Table 3-1: Template distribution based on template type

Template typeNumber of template
Cell9
Virus18
Protein>Monoclonal antibody5
Protein>Polyclonal antibody2
Protein>Receptor33
Protein>Enzyme33
Protein>Others310
Nucleic acids2
Organic molecules or materials46
Inorganic molecules or materials4
Miscellaneous3

 

Table 3-2: Template distribution based on template source

Template sourceNumber of template
Homo sapiens (Human)175
Mus musculus (Mouse)16
Others227
Unknown35
None13

 

Structure:

 

Table 4: Complex structure and related mimotope sets

ComplexTarget-templateTarget-peptideIn Total
Structure number22336259
Related mimotope sets16410174*
Related targets66874*
Related templates60666*

 

Library:

 

In the current version of the MimoDB database, there are 403 phage libraries or library pools.

 

Table 5-1: Library distribution based on randomness

Library randomnessNumber of library
Completely random276
Semi-random127

 

Table 5-2: Library distribution based on topology

Library topologyNumber of library
Linear236
Circular134
Mixture(linear, circular)33