Think before you leap; SAROTUP before you reap!
SAROTUP is originally short for "Scanner And Reporter Of Target-Unrelated Peptides". Now it has been developed into a suite of tools which can be used to scan, report and exclude possible target-unrelated peptides from biopanning results. In the SAROTUP suite, the TUPScan tool finds peptides with known TUP motifs in your query sequences; the MimoScan tool reports peptides in the BDB database that match your query patterns; the MimoSearch and MimoBlast tools check if there are peptides in the BDB database that are identical or similar to yours; the PhD7Faster 2.0 tool on the TUPredict page can predict if phages bearing your peptides from the Ph.D.-7 phage display library might grow faster; the SABinder tool on the TUPredict page can foretell if phages bearing your peptides would bind to streptavidin; the PSBinder tool on the TUPredict page can detect polystyrene surface-binding peptides (PSBP). All tools in the SAROTUP suite have been redeveloped using C++ language. Accordingly, SAROTUP is also distributed as an open source package, which can perform perfectly natively on different systems. These tools can be used in basic study such as epitope mapping based on phage display and applied research such as development of diagnostics, therapeutics and vaccines based on mimotopes. Using SAROTUP first would help to keep your study away from "garbage in, garbage out" effects and save labor, money and time for you.
