BDB - Target Details

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Target
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Structure

Target

Target Name: Coagulation factor XIII A chain

Target ID:

Target Type:

Protein>Enzyme

Target Sequence:

P00488

Synonyms:

Coagulation factor XIIIa
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
EC=2.3.2.13

Target Source:

Homo sapiens (Human):9606

Target Structure:

1EVU, 1EX0, 1F13, 1FIE, 1GGT, 1GGU, 1GGY, 1QRK

Comments:

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

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